Kontogeorgos G, Kovacs K, Scheithauer B W, Rologis D, Orphanidis G
Department of Pathology, St. Michael's Hospital, University of Toronto, Ontario, Canada.
Mod Pathol. 1991 Mar;4(2):191-5.
Twelve plurihormonal pituitary adenomas, removed surgically from 11 of 20 patients with acromegaly, were investigated. The mean age of the 11 patients was 45 yr. Seven patients with eight tumors were men. The tumors were immunostained for all known adenohypophysial hormones by the avidin-biotin-peroxidase complex (ABC) technique. All 12 adenomas were immunoreactive for growth hormone (GH) and alpha-subunit; prolactin (PRL) was detected in five tumors. Stains for the beta-subunits of glycoprotein hormones [thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), and luteinizing hormone (LH)] revealed immunopositivity for specific beta-subunits in ten adenomas. The close association between GH and alpha-subunit in pituitary tumors of acromegalic patients remains to be explained.
对从20例肢端肥大症患者中的11例手术切除的12例多激素垂体腺瘤进行了研究。11例患者的平均年龄为45岁。7例患者患有8个肿瘤，均为男性。采用抗生物素蛋白-生物素-过氧化物酶复合物（ABC）技术对所有已知腺垂体激素进行肿瘤免疫染色。所有12例腺瘤对生长激素（GH）和α亚基均呈免疫反应；在5个肿瘤中检测到催乳素（PRL）。糖蛋白激素β亚基[促甲状腺激素（TSH）、促卵泡激素（FSH）和促黄体生成素（LH）]染色显示，10例腺瘤中特定β亚基呈免疫阳性。肢端肥大症患者垂体肿瘤中GH与α亚基之间的密切关联仍有待解释。
