Anderson D M, Brydon W G, Eastwood M A, Sedgwick D M
Chemistry Department, The University, Edinburgh, UK.
Food Addit Contam. 1991 May-Jun;8(3):225-36. doi: 10.1080/02652039109373973.
Following a 7-day control period, five male volunteers consumed a weight of propylene glycol alginate corresponding to 175 mg/kg body weight for 7 days, followed by 200 mg propylene glycol alginate per kg body weight for a further 16 days. Measurements before and at the end of the 23-day period of dietary supplementation showed that propylene glycol alginate had little effect on faecal parameters (pH, water content, daily wet and dry weights). The dietary transit time remained constant for three volunteers, increased for one, and decreased for one. The ingestion of propylene glycol alginate had no significant effect on (a) haematological indices, (b) plasma biochemistry parameters, (c) urinalysis parameters, (d) blood glucose and plasma insulin concentrations, (e) breath hydrogen concentrations. No allergic responses were reported by, nor observed in, any of the volunteers. The study therefore indicates that the ingestion of propylene glycol alginate at a high level for 23 days caused no adverse dietary or physiological effects; in particular, the enzymatic and other sensitive indicators of adverse toxicological effects remained unchanged.
在为期7天的对照期后，5名男性志愿者连续7天摄入了相当于175毫克/千克体重的藻酸丙二醇酯，随后又在接下来的16天里每天每千克体重摄入200毫克藻酸丙二醇酯。在为期23天的膳食补充期开始前和结束时所进行的测量表明，藻酸丙二醇酯对粪便参数（pH值、含水量、每日湿重和干重）几乎没有影响。三名志愿者的饮食通过时间保持不变，一名志愿者的饮食通过时间增加，一名志愿者的饮食通过时间减少。摄入藻酸丙二醇酯对（a）血液学指标、（b）血浆生化参数、（c）尿液分析参数、（d）血糖和血浆胰岛素浓度、（e）呼气中氢气浓度均无显著影响。所有志愿者均未报告或观察到过敏反应。因此，该研究表明，连续23天高水平摄入藻酸丙二醇酯不会产生不良的饮食或生理影响；特别是，不良毒理学效应的酶学及其他敏感指标均未改变。
