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[俄罗斯人群中HLA Ⅱ类抗原的血清学多态性]

[Serologic polymorphism of the HLA Class 2 antigens in the Russian population].

作者信息

Abramov V Iu, Zaretskaia Iu M, Kaluzhina N N, Otocheva L V

出版信息

Genetika. 1991 Sep;27(9):1658-61.

PMID:1778464
Abstract

Two hundred and thirty Russian Moscovities (108 healthy individuals and 122 cadaver kidney donors) were typed for antigens HLA-DR1-DRw10, HLA-DRw52-DRw53, and HLA-DQw1 and DQw3. HLA-DR1, 2, 3, 4, 5 and 7 were investigated in all individuals, the other having been only studied in portions of the material. The HLA class 2 antigens' polymorphism in Russian population has been shown to have features common to all Caucasians. Most widely distributed antigen is DR2 (phenotype frequency is 36%). Antigens DRw8, DR9 and DRw10 are rare. DR allele distribution demonstrated perfect fits to Hardy--Weinberg expectations. Antigens DR5 and DR4 are considered most difficult to define at early stage of the study.

摘要

对230名俄罗斯莫斯科人(108名健康个体和122名尸体肾供体)进行了HLA - DR1 - DRw10、HLA - DRw52 - DRw53以及HLA - DQw1和DQw3抗原分型。对所有个体研究了HLA - DR1、2、3、4、5和7,其他抗原仅在部分材料中进行了研究。已表明俄罗斯人群中HLA -Ⅱ类抗原的多态性具有所有高加索人的共同特征。分布最广泛的抗原是DR2(表型频率为36%)。抗原DRw8、DR9和DRw10很罕见。DR等位基因分布与哈迪 - 温伯格预期完全相符。在研究的早期阶段,DR5和DR4抗原被认为最难鉴定。

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