LeGoff Jérôme, Saussereau Elodie, Boulanger Marie-Christine, Chemin Cécile, Si-Mohamed Ali, Bélec Laurent, Maisonneuve Lydia
Université Paris V, Unité Inserm 743, Equipe Immunité et biothérapie muqueuse, Centre de Recherches Biomédicales des Cordeliers, Paris, France.
Int J STD AIDS. 2007 Sep;18(9):593-5. doi: 10.1258/095646207781568457.
Both herpes simplex virus type 2 (HSV-2) seroprevalence and the proportion of HSV-1 genital ulcers are increasing in industrialized countries. The consequences of these epidemiological changes, in pregnant women in France, for both the genital shedding of HSV and vertical transmission, have been poorly evaluated. The HSV-1 and HSV-2 seroprevalence and the rate of subclinical genital shedding of herpes close to delivery were evaluated in pregnant women, with no history of genital herpes, living in the East Paris suburban area. HSV-2 antibody prevalence of 26% was significantly associated with country of origin and was higher than that reported in 2002 in French women from the general population (18%). HSV-2 and HSV-1 genital reactivations were observed in 10% of HSV-2 seropositive and in 4% of HSV-1 seropositive and HSV-2 seronegative women, respectively. The high rates of HSV-2 seropositivity and subclinical herpes genital shedding observed in this study should be considered to promote a national survey in pregnant women to propose strategies to prevent the spread of HSV within the population and to the neonate.
在工业化国家，2型单纯疱疹病毒（HSV-2）的血清流行率和HSV-1生殖器溃疡的比例都在上升。在法国，这些流行病学变化对孕妇HSV生殖器排毒和垂直传播的影响尚未得到充分评估。对居住在巴黎东郊、无生殖器疱疹病史的孕妇进行了HSV-1和HSV-2血清流行率以及接近分娩时疱疹亚临床生殖器排毒率的评估。26%的HSV-2抗体流行率与原籍国显著相关，且高于2002年法国普通人群中女性的报告率（18%）。分别在10%的HSV-2血清阳性女性和4%的HSV-1血清阳性且HSV-2血清阴性女性中观察到HSV-2和HSV-1生殖器复发。本研究中观察到的HSV-2血清阳性率和亚临床疱疹生殖器排毒率较高，应考虑开展全国性的孕妇调查，以提出预防HSV在人群中传播并传染给新生儿的策略。
