细胞色素P450与人类癌症
P450 and human cancer.
作者信息
Kawajiri K, Fujii-Kuriyama Y
机构信息
Department of Biochemistry, Saitama Cancer Center Research Institute.
出版信息
Jpn J Cancer Res. 1991 Dec;82(12):1325-35. doi: 10.1111/j.1349-7006.1991.tb01800.x.
Abstract
Most of the chemical carcinogens in our environment are activated mainly by a restricted number of cytochrome P450 species, P450 1A1, 1A2, 2E1, and 3A. This metabolic activation of procarcinogens is a crucial part of the initial host response to the environmental exposure, since most chemical carcinogens do not show any carcinogenicity by themselves. Inter-individual variability in the metabolic activity may thus be a key host factor to explain the differences in susceptibility to chemical carcinogenesis among individuals. Recent studies on P450s in cancer etiology have provided some valuable insights into this problem.
摘要
我们环境中的大多数化学致癌物主要由数量有限的细胞色素P450同工酶激活，即P450 1A1、1A2、2E1和3A。前致癌物的这种代谢激活是宿主对环境暴露初始反应的关键部分，因为大多数化学致癌物本身并不显示任何致癌性。代谢活性的个体间差异因此可能是解释个体对化学致癌易感性差异的关键宿主因素。最近关于细胞色素P450在癌症病因学方面的研究为这个问题提供了一些有价值的见解。
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