Science. 1988 Sep 16;241(4872):1475-9. doi: 10.1126/science.241.4872.1475.
Mixed single crystals composed of host and guest organic molecules of similar structures and shapes are shown to comprise sectors with different host-guest distributions and to have symmetries lower than that of the host crystal. These properties are determined by the structure of the guest and the surface structures of the crystal faces through which the guest molecules are occluded. This general concept is illustrated by studies of three mixed crystal systems,(E)-cinnamamide-(E)-2-thienylacrylamide, (E)-cinnamamide-(E)-3-thienylacrylamide, and(S)-asparagine-(S)-aspartic acid, with x-ray and neutron diffraction and solid-state photochemistry.
由具有相似结构和形状的主客体有机分子组成的混合单晶被证明包含具有不同主客体分布的区域，并且具有低于主体晶体的对称性。这些性质是由客体的结构和通过其包含客体分子的晶面的表面结构决定的。通过对三种混合晶体系统的研究(E)-肉桂酰胺-(E)-2-噻吩丙烯酰胺、(E)-肉桂酰胺-(E)-3-噻吩丙烯酰胺和(S)-天冬酰胺-(S)-天冬氨酸，用 X 射线和中子衍射以及固态光化学，说明了这一普遍概念。
