Holcomb M, Korfmacher W A, Thompson H C
Food and Drug Administration, Division of Chemistry, Jefferson, Arkansas 72079.
J Anal Toxicol. 1991 Nov-Dec;15(6):289-92. doi: 10.1093/jat/15.6.289.
Thermospray mass spectrometry (TSMS) was used to identify the derivatives formed when iodine is reacted with aflatoxins B1 and G1 at approximately 70 degrees C to enhance fluorescence. It was found that stable derivatives were formed by addition of an iodine atom and a methoxy group across the double bond located on the furan ring of the aflatoxin B1 and G1 molecules. TSMS and TSMS/MS daughter spectra of the reaction products of aflatoxin B1 and G1 with iodine provide evidence of the addition of each moiety to produce the iodo-methoxy derivative. The addition of an iodine atom to one carbon and a methoxy group to the other carbon of the furan ring provided molecular weights of 470 and 486 for the products of aflatoxin B1 and G1, respectively.
热喷雾质谱法（TSMS）用于鉴定在约70摄氏度下碘与黄曲霉毒素B1和G1反应以增强荧光时形成的衍生物。结果发现，通过在黄曲霉毒素B1和G1分子呋喃环上的双键处添加一个碘原子和一个甲氧基，形成了稳定的衍生物。黄曲霉毒素B1和G1与碘反应产物的TSMS和TSMS/MS子光谱提供了各部分加成生成碘代甲氧基衍生物的证据。在呋喃环的一个碳原子上添加一个碘原子，在另一个碳原子上添加一个甲氧基，黄曲霉毒素B1和G1产物的分子量分别为470和486。
