Monti J M, Carlini E A
Pharmacol Biochem Behav. 1975 Nov-Dec;3(6):1025-9. doi: 10.1016/0091-3057(75)90011-8.
The correlation between marihuana-induced aggressive behavior and changes in the sleep-wakefulness cycle was studied in chronically implanted rats. Marihuana injection in non-REM deprived rats did not induce aggressiveness irrespective of the animals being caged in isolation or paired. During this procedure quantization of the sleep-awake cycle revealed that wakefulness was increased while slow wave and REM sleep were decreased, mainly in the paired animals. REM deprived-marihuana injected animals recorded in isolation behaved like the control solution-injected rats. They showed a large rebound of REM and were not aggressive at the end of the 8 hr sessions. Conversely, when these animals were paired during the recording periods, they remained continuously awake and showed numerous episodes of aggressiveness. These results suggest that the aggressiveness inducing properties of marihuana are related to the REM deprivation and to the increased environmental stimulation achieved by pairing the animals.
在长期植入电极的大鼠中研究了大麻诱导的攻击行为与睡眠-觉醒周期变化之间的相关性。无论动物是单独饲养还是成对饲养，对未被剥夺快速眼动睡眠（REM）的大鼠注射大麻均不会诱发攻击性。在此过程中，对睡眠-觉醒周期进行量化显示，主要是在成对饲养的动物中，觉醒增加，而慢波睡眠和快速眼动睡眠减少。单独记录的被剥夺快速眼动睡眠并注射大麻的动物表现得与注射对照溶液的大鼠相似。它们表现出快速眼动睡眠的大幅反弹，并且在8小时实验结束时没有攻击性。相反，当在记录期间将这些动物成对饲养时，它们持续保持清醒，并表现出多次攻击行为。这些结果表明，大麻的攻击性诱导特性与快速眼动睡眠剥夺以及通过将动物成对饲养所实现的环境刺激增加有关。
