Reinecke R K, Lourens M, Petersen B
Overberg Research Projects, University of Pretoria, South Africa.
Onderstepoort J Vet Res. 1991 Dec;58(4):285-90.
Two field trials, one with suckling Merino ewe lambs and the other with yearling Dohne Merino rams, are described. In these the anthelmintic efficacy of febantel (a benzimidazole), ivermectin, levamisole and morantel are compared, using the 1st stage larval reduction test. The mean natural log (+1 for zero values) of the post treatment larval counts of the treated groups was compared with that of the untreated controls and the percentage reduction used to assess anthelmintic efficacy. Febantel was only 87.4% effective against Teladorsagia in suckling lambs but the other anthelmintics were more than 99% effective against this genus. Efficacy against Haemonchus and Trichostrongylus ranged from 93.2%-100% for all 4 compounds. In the rams all compounds were 100% effective against Trichostrongylus, with the exception of morantel which was only 87.5% effective. None of the compounds were effective against Teladorsagia, particularly morantel, animals treated with which having more larvae than the controls. The interpretation of anthelmintic efficacy; the advantages of the first stage larval reduction test, compared with the faecal egg count reduction test; and the importance of incubating cultures at 30 degrees C for 24 h, in order to harvest first stage larvae, are discussed.
本文描述了两项田间试验，一项针对哺乳美利奴母羊羔，另一项针对一岁多的多内美利奴公羊。在这些试验中，使用第一阶段幼虫减少试验比较了非班太尔（一种苯并咪唑）、伊维菌素、左旋咪唑和莫仑太尔的驱虫效果。将治疗组治疗后幼虫计数的平均自然对数（零值为 +1）与未治疗对照组的进行比较，并使用减少百分比来评估驱虫效果。非班太尔对哺乳羔羊体内的细颈线虫仅87.4%有效，但其他驱虫药对该属的有效性超过99%。对血矛线虫和毛圆线虫的有效性，这4种化合物的范围为93.2% - 100%。在公羊中，所有化合物对毛圆线虫的有效性均为100%，但莫仑太尔除外，其有效性仅为87.5%。没有一种化合物对细颈线虫有效，尤其是莫仑太尔，用其治疗的动物体内的幼虫比对照组更多。文中还讨论了驱虫效果的解读；与粪便虫卵计数减少试验相比，第一阶段幼虫减少试验的优势；以及为了收获第一阶段幼虫，在30摄氏度下将培养物孵育24小时的重要性。
