Kasim Y A, Anky Tri Rini K E, Sumarmo S P
Department of Child Health, Medical School University of Indonesia, Jakarta.
Paediatr Indones. 1991 Sep-Oct;31(9-10):245-52.
Many studies of Dengue Hemorrhagic Fever (DHF) have been done but only a few revealed the respiratory status. Respiratory problems arise because of plasma leakage through the damaged capillaries, causing lung edema and in turn result in hypoxemia. This later on will be compensated by a hyperventilation state. During a 6-month-period (May to September 1988), two aspects were studied in 85 patients hospitalized with DHF. First, the ventilatory pattern and second, the result of giving oxygen support in improving the respiratory disturbance, in this case alveolar hyperventilation. The incidence of alveolar hyperventilation in DHF grade II (DHF II) and Dengue Shock Syndrome (DSS) differed significantly. Hypoxemia occurred in DHF II and DSS with no significant differences. The difference of the incidence of metabolic acidosis in DHF II and DSS were significant. In DHF II patients having had hyperventilation state, oxygen therapy decreased respiration rate significantly and increased the PaCO2 though not significantly.
许多关于登革出血热（DHF）的研究已经开展，但只有少数研究揭示了呼吸状况。呼吸问题是由于血浆通过受损的毛细血管渗漏，导致肺水肿，进而引起低氧血症。随后，这将通过过度通气状态得到代偿。在1988年5月至9月的6个月期间，对85例因登革出血热住院的患者进行了两方面的研究。第一，通气模式；第二，给予氧疗改善呼吸障碍（即肺泡过度通气）的效果。登革出血热二级（DHF II）和登革休克综合征（DSS）中肺泡过度通气的发生率有显著差异。低氧血症在DHF II和DSS中均有发生，无显著差异。DHF II和DSS中代谢性酸中毒发生率的差异显著。在处于过度通气状态的DHF II患者中，氧疗显著降低了呼吸频率，虽未显著提高动脉血二氧化碳分压（PaCO2），但使其有所升高。
