Guneratne J R, Gard D I
Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, Indiana 46140.
Poult Sci. 1991 Sep;70(9):1888-94. doi: 10.3382/ps.0701888.
Continuous programs of a combination of narasin (40 ppm) and nicarbazin (40 ppm) (NaNi), narasin at levels of 60 and 70 ppm, and a 2 by 2 factorial shuttle design (NaNi or nicarbazin at 125 ppm, each for 27 or 28 days, followed by narasin at 60 or 70 ppm to termination), were compared with unmedicated controls for their anticoccidial efficacy and growth performance in nine broiler trials conducted in seven countries outside the United States. Cecal coccidial lesions were reduced only by treatments that incorporated nicarbazin either at the 40-ppm level in NaNi or at 125 ppm, whereas total intestinal lesion scores were reduced by all the anticoccidial programs tested. At Day 28, the three treatments containing NaNi and the treatment containing narasin at 60 ppm significantly improved weight gain and feed efficiencies over the two treatments containing nicarbazin at 125 ppm and the unmedicated controls. At termination all the anticoccidial programs significantly decreased the mortality rate and improved bird weights and feed efficiencies. Birds on the treatments containing NaNi either in the two shuttle programs or in the continuous program were significantly heavier than those on the two treatments containing nicarbazin at 125 ppm in shuttle programs.
在美国境外七个国家进行的九项肉鸡试验中，将那拉菌素（40 ppm）和尼卡巴嗪（40 ppm）组合（NaNi）的连续方案、60 ppm和70 ppm水平的那拉菌素，以及2×2析因穿梭设计（125 ppm的NaNi或尼卡巴嗪，各持续27或28天，随后是60或70 ppm的那拉菌素直至试验结束），与未用药的对照组在抗球虫效果和生长性能方面进行了比较。仅通过在NaNi中以40 ppm水平添加尼卡巴嗪或在125 ppm添加尼卡巴嗪的处理，盲肠球虫病变有所减少，而所有测试的抗球虫方案均降低了肠道病变总评分。在第28天，与两种含有125 ppm尼卡巴嗪的处理和未用药对照组相比，三种含有NaNi的处理以及含有60 ppm那拉菌素的处理显著提高了体重增加和饲料效率。试验结束时，所有抗球虫方案均显著降低了死亡率，并提高了鸡的体重和饲料效率。在两个穿梭方案或连续方案中接受含NaNi处理的鸡，比在穿梭方案中接受两种含125 ppm尼卡巴嗪处理的鸡明显更重。
