Bull R J, O'Neill J J
Psychopharmacol Commun. 1975;1(1):109-15.
Elevation of the media potassium concentration results in an immediate, but transient increase in the rate of respiration in cerebral cortex slices of the rat. As the respiratory burst decrease in intensity, a transient oxidation of the tissue respiratory intermediates is followed by a net reduction. The burst of respiration is accompanied by a large decrease in tissue ATP and phosphocreatine concentrations. ATP and phosphocreatine concentrations are essentially fully recovered within 5-6 min. The apparent increase in ATP hydrolysis during the peak of the respiratory response was not, however, accompanied by increases in the tissue content of ADP and 5'-AMP. Increased deamination of the adenine nucleotides is discussed as a possible mechanism in the large contraction of the total adenine pool observed during the course of the metabolic response to elevated potassium concentrations.
培养基钾浓度升高会导致大鼠大脑皮层切片的呼吸速率立即但短暂地增加。随着呼吸爆发强度的降低，组织呼吸中间产物会出现短暂的氧化，随后是净还原。呼吸爆发伴随着组织ATP和磷酸肌酸浓度的大幅下降。ATP和磷酸肌酸浓度在5 - 6分钟内基本完全恢复。然而，在呼吸反应峰值期间ATP水解的明显增加并没有伴随着ADP和5'-AMP组织含量的增加。腺嘌呤核苷酸脱氨基作用增加被认为是在对钾浓度升高的代谢反应过程中观察到的总腺嘌呤池大幅收缩的一种可能机制。
