Andrecut M, Kauffman S A
Institute for Biocomplexity and Informatics, University of Calgary, Calgary, Alberta, Canada.
J Comput Biol. 2007 Sep;14(7):973-83. doi: 10.1089/cmb.2007.0038.
We show that there is a physical analogy between a stochastic model of a genetic toggle switch system and a thermostated particle moving in a potential field, derived from the probability distribution of the toggle switch. This result suggests that one can actually simulate the dynamics of a more complex gene network by considering an ensemble of thermostated particles moving in a potential field, derived from the stationary distribution of the chemical stochastic model describing the gene network.
我们表明,遗传 Toggle 开关系统的随机模型与在势场中运动的恒温粒子之间存在物理类比,这是从 Toggle 开关的概率分布推导出来的。这一结果表明,人们实际上可以通过考虑在势场中运动的恒温粒子系综来模拟更复杂基因网络的动力学,该势场是从描述基因网络的化学随机模型的平稳分布推导出来的。