Hetherington M M, Vervaet N, Blass E, Rolls B J
Department of Psychology, University of Dundee, Scotland.
Pharmacol Biochem Behav. 1991 Sep;40(1):185-90. doi: 10.1016/0091-3057(91)90343-z.
Two separate studies were conducted to investigate the effects of oral naltrexone on the pleasantness ratings of foods and food intake. In both studies, normal-weight, nondieting males rated hunger, fullness, mood and the pleasantness of the taste of a variety of foods before and after double-blind administration of 50 mg of naltrexone or placebo. All subjects received a test meal, in a counterbalanced, repeated measures design. In the first study, 12 subjects were given a self-selection test meal after overnight deprivation. In the second study 14 subjects were given an ice cream test meal with no deprivation. In both experiments the pleasantness of the taste of the foods, sensory-specific satiety, hunger ratings and overall energy intake were not differentially influenced by naltrexone administration. In Experiment 2, intake of the ice cream was greater after active drug administration because subjects who received active drug on the first session ate less ice cream in the placebo session. In conclusion, in the short term, naltrexone had no impact on hunger, sensory-specific satiety or food intake.
进行了两项独立研究，以调查口服纳曲酮对食物愉悦度评分和食物摄入量的影响。在这两项研究中，体重正常、不节食的男性在双盲服用50毫克纳曲酮或安慰剂前后，对饥饿感、饱腹感、情绪以及多种食物味道的愉悦度进行评分。所有受试者均采用平衡的重复测量设计接受一次测试餐。在第一项研究中，12名受试者在禁食过夜后接受自选测试餐。在第二项研究中，14名受试者在不禁食的情况下接受冰淇淋测试餐。在这两项实验中，纳曲酮给药对食物味道的愉悦度、感官特异性饱腹感、饥饿评分和总体能量摄入均无差异影响。在实验2中，服用活性药物后冰淇淋的摄入量更大，因为在第一阶段接受活性药物的受试者在安慰剂阶段吃的冰淇淋较少。总之，短期内，纳曲酮对饥饿感、感官特异性饱腹感或食物摄入量没有影响。
