Atherosclerosis Research Unit, King Gustaf V Research Institute, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Clin Endocrinol (Oxf). 2008 Jan;68(1):51-8. doi: 10.1111/j.1365-2265.2007.02998.x. Epub 2007 Sep 4.
IGF-I, IGFBP-1 and IGFBP-3 are putative mediators in cardiovascular disease. The present study examined (i) the correlations of circulating IGF-I, IGFBP-1 and IGFBP-3 to established cardiovascular risk factors and signs of early atherosclerosis as reflected by ultrasound measurement of common carotid intima-media thickness (IMT), and (ii) whether serum concentrations of these analytes are modulated during alimentary lipaemia.
Cross-sectional clinical study.
A biobank and clinical database based on 96 healthy Caucasian men, aged 50 years, with an apolipoprotein (apo) E3/E3 genotype, who had originally undergone investigations of postprandial lipoprotein metabolism was used for the study.
Total IGF-I, IGFBP-1 and IGFBP-3 were determined in serum by radioimmunoassay (RIA). Free IGF-I was measured by a commercial two-site immunoradiometric assay (IRMA).
In multivariate analyses, fasting serum free IGF-I correlated inversely with IMT and accounted for 5% of the variation in multiple R(2). When fasting serum IGFBP-1 was entered in the models instead of IGF-I, IGFBP-1 correlated positively with IMT and accounted for 6% of the variation in IMT. IGFBP-3 and total IGF-I were unrelated to IMT. There were no associations between free IGF-I and cardiovascular risk factors, whereas IGFBP-1 behaved like a component of the insulin resistance syndrome. Serum free IGF-I increased and IGFBP-1 decreased postprandially.
The data indicate that serum free IGF-I and IGFBP-1 are implicated in early atherosclerosis.
IGF-I、IGFBP-1 和 IGFBP-3 是心血管疾病的潜在介质。本研究探讨了（i）循环 IGF-I、IGFBP-1 和 IGFBP-3 与已建立的心血管危险因素以及通过超声测量颈总动脉内膜中层厚度（IMT）反映的早期动脉粥样硬化迹象的相关性，以及（ii）这些分析物的血清浓度是否在饮食性脂血症期间发生调节。
横断面临床研究。
基于 96 名年龄 50 岁、载脂蛋白（apo）E3/E3 基因型的健康白种人，最初接受餐后脂蛋白代谢研究的生物库和临床数据库，用于本研究。
通过放射免疫测定（RIA）在血清中测定总 IGF-I、IGFBP-1 和 IGFBP-3。游离 IGF-I 通过商业双位点免疫放射测定（IRMA）测定。
在多元分析中，空腹血清游离 IGF-I 与 IMT 呈负相关，占 R2 变化的 5%。当空腹血清 IGFBP-1 替代 IGF-I 进入模型时，IGFBP-1 与 IMT 呈正相关，占 IMT 变化的 6%。IGFBP-3 和总 IGF-I 与 IMT 无关。游离 IGF-I 与心血管危险因素之间没有关联，而 IGFBP-1 表现为胰岛素抵抗综合征的组成部分。空腹血清游离 IGF-I 增加，IGFBP-1 餐后减少。
数据表明，血清游离 IGF-I 和 IGFBP-1 与早期动脉粥样硬化有关。
