Jönsson Maria, Norrgård Orjan, Hansson Magnus, Forsgren Sture
Department of Integrative Medical Biology, Anatomy, Umeå University, SE-901 87 Umeå, Sweden.
Ann N Y Acad Sci. 2007 Jun;1107:280-9. doi: 10.1196/annals.1381.030.
The neuropeptide vasoactive intestinal peptide (VIP) is involved in the neuroimmunomodulation of the intestine. In the present study, specimens from the sigmoid colon of ulcerative colitis (UC) and non-UC patients were examined for immunohistochemistry and in vitro receptor autoradiography. Marked occurrence of VIP binding was observed in the mucosa. However, there were very low levels of binding in areas showing pronounced inflammation/derangement. The study shows that marked derangement of the mucosa leads to a distinct decrease in VIP binding. Thus, it is possible that a decrease in trophic and anti-inflammatory VIP effects occurs in areas exhibiting a very marked inflammation.
神经肽血管活性肠肽（VIP）参与肠道的神经免疫调节。在本研究中，对溃疡性结肠炎（UC）患者和非UC患者的乙状结肠标本进行了免疫组织化学检查和体外受体放射自显影。在黏膜中观察到VIP结合明显存在。然而，在显示明显炎症/紊乱的区域，结合水平非常低。该研究表明，黏膜的明显紊乱导致VIP结合显著减少。因此，在表现出非常明显炎症的区域，可能会出现营养性和抗炎性VIP作用的降低。
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