Rule R, Rubio M, Perelli M C
CIC Provincia de Buenos Aires, Cátedra de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina.
Res Vet Sci. 1991 Nov;51(3):233-8. doi: 10.1016/0034-5288(91)90069-z.
Serum, tissue and peritoneal fluid concentrations of ceftazidime were studied in ewes after intravenous, intramuscular and subcutaneous administration at 50 mg kg-1 bodyweight. Tissue and peritoneal cages were implanted in the animals studied. After intravenous bolus administration, the mean serum concentration versus time profile was best described by a two-compartment open model. The distribution rate constant (alpha) was 3.5 +/- 1.1 h-1 and the half-life (t 1/2 alpha) 0.22 +/- 0.09 hour. The elimination rate constant (beta) was 0.43 +/- 0.04 h-1 and half-life (t 1/2 beta) 1.6 +/- 0.2 hours. The area under the curve was 275.7 +/- 84.0 micrograms.ml-1 h. The volume of distribution as steady state was 356.1 +/- 208.0 ml kg-1. The penetration ratio into tissue fluid was 62.6 +/- 15.1 per cent and into peritoneal fluid 61.1 +/- 16.5 per cent. After intramuscular injection, the elimination half-life was 1.7 +/- 0.2 hours, the area under the curve was 228.7 +/- 43.3 micrograms.ml-1 h. and the elimination rate constant was 0.42 +/- 0.05 h-1. The penetration ratio into tissue fluid was 68.5 +/- 37.3 per cent and into peritoneal fluid 73.3 +/- 34.4 per cent. After subcutaneous injection, the elimination half-life was 1.8 +/- 0.5 hours, the area under the curve was 231.8 +/- 65.6 micrograms.ml-1 h. and the elimination constant was 0.41 +/- 0.10 h-1. The penetration ratio into tissue fluid was 47.2 +/- 3.5 per cent and into peritoneal fluid 58.1 +/- 15.6 per cent.(ABSTRACT TRUNCATED AT 250 WORDS)
以50mg/kg体重对母羊进行静脉内、肌肉内和皮下给药后，研究了头孢他啶在血清、组织和腹水中的浓度。在受试动物体内植入组织和腹水收集装置。静脉推注给药后，血清浓度-时间曲线最佳拟合为二室开放模型。分布速率常数（α）为3.5±1.1 h-1，半衰期（t 1/2α）为0.22±0.09小时。消除速率常数（β）为0.43±0.04 h-1，半衰期（t 1/2β）为1.6±0.2小时。曲线下面积为275.7±84.0μg·ml-1·h。稳态分布容积为356.1±208.0 ml/kg。组织液渗透比为62.6±15.1%，腹水渗透比为61.1±16.5%。肌肉注射后，消除半衰期为1.7±0.2小时，曲线下面积为228.7±43.3μg·ml-1·h，消除速率常数为0.42±0.05 h-1。组织液渗透比为68.5±37.3%，腹水渗透比为73.3±34.4%。皮下注射后，消除半衰期为1.8±0.5小时，曲线下面积为231.8±65.6μg·ml-1·h，消除常数为0.41±0.10 h-1。组织液渗透比为47.2±3.5%，腹水渗透比为58.1±15.6%。（摘要截取自250字）
