Martucci C, Fishman J
Steroids. 1976 Mar;27(3):325-33. doi: 10.1016/0039-128x(76)90054-4.
The binding affinities for the catecholestrogen metabolites of estradiol and of their methyl ethers for the rat uterine cytosol estrogen receptors were examined. Similarly the binding of the fetal estradiol metabolite, 15alpha-hydroxyestriol (estertrol) was also measured. All of the catecholestrogens showed binding affinities far in excess of their uterotrophic potency. This is different from estriol, the product of the alternative metabolic pathways and suggests that the direction of estradiol metabolism may have an important role in the modulation of estrogenic activity of the female sex hormone.
研究了雌二醇及其甲基醚的儿茶酚雌激素代谢物与大鼠子宫胞质溶胶雌激素受体的结合亲和力。同样，也测定了胎儿雌二醇代谢物15α-羟基雌三醇（依斯特罗）的结合情况。所有儿茶酚雌激素显示出的结合亲和力远远超过其子宫营养效能。这与替代代谢途径的产物雌三醇不同，表明雌二醇代谢方向可能在调节女性性激素的雌激素活性中起重要作用。
