Kusayama T, Tomatsu T, Akasaka O, Imai N
Department of Orthopaedic Surgery, School of Medicine, Tokai University, Kanagawa, Japan.
Tokai J Exp Clin Med. 1991 Jul;16(2):145-51.
Many methods have been attempted to repair defects in the articular cartilage involving the subchondral bone, but no satisfactory method has yet been established. We performed an experimental study utilizing autogenous meniscus grafts for defects in the articular cartilage involving the subchondral bone. Sixty-two knees of 31 rabbits were thus treated. Gross and histological examinations were performed in animals sequentially sacrificed after 2 to 24 weeks. In gross examinations, the articular surface was smooth and the degenerative changes were slight although the grafted area appeared as a piece of whitish meniscus in all experimental knees. Histologically, 12 weeks were necessary for complete union in the superficial zone of the junction between the grafted meniscus and the subchondral bone. However, the junction in the deep zone was completely united after two weeks. Degenerative changes, such as fibrillation or ulceration were not noted on the surface of the grafted meniscus. The chondrocytes of the meniscus survived for as long as 24 weeks. The autogenous meniscus graft appears to be a promising alternative for defects in the articular cartilage.
人们尝试了多种方法来修复涉及软骨下骨的关节软骨缺损，但尚未建立令人满意的方法。我们利用自体半月板移植对涉及软骨下骨的关节软骨缺损进行了一项实验研究。对31只兔子的62个膝关节进行了这样的治疗。在2至24周后对依次处死的动物进行大体和组织学检查。在大体检查中，尽管在所有实验膝关节中移植区域呈现为一片白色半月板，但关节表面光滑，退变变化轻微。组织学上，移植半月板与软骨下骨交界处的表层完全愈合需要12周。然而，深层交界处两周后就完全愈合了。移植半月板表面未发现如纤维化或溃疡等退变变化。半月板的软骨细胞存活长达24周。自体半月板移植似乎是关节软骨缺损的一种有前景的替代方法。
