Meshcheriakov A V, Nurmatov U B, Vinnitskiĭ L I, Dement'eva I I, Egorova I A
Vestn Akad Med Nauk SSSR. 1991(7):21-4.
The authors analyze the results of measuring the content of vasopressin, renin, angiotensin II and aldosterone coupled with the results of studying hemodynamics, acid-base state, and lactate in the arterial blood during operations on the heart in 32 patients with different acquired heart diseases. The main attention was concentrated on studies into the nature of humoral changes during extracorporeal circulation in three types of anesthesia. In group I, anesthesia was maintained by fentanyl given in a dose of 5-6 micrograms/kg/h, diazepam (0.1 mg/kg/h), and arduan (0.02 mg/kg/h). In the second observation group, at the beginning of perfusion the patients were administered trimetotan (artonad) (0.2 mg/kg), and in group III, the dose of fentanyl was raised during perfusion to 10-12 micrograms/kg/h. It is concluded that during extracorporeal circulation, it is desirable that the dose of fentanyl be increased to attain more adequate anesthesia in that period of heart surgery. The magnitude of humoral changes occurring in the body during extracorporeal circulation served as a criterion for anesthesia adequacy.
作者分析了32例患有不同后天性心脏病患者在心脏手术期间测量血管加压素、肾素、血管紧张素II和醛固酮含量的结果，以及研究动脉血中血流动力学、酸碱状态和乳酸的结果。主要关注点集中在三种麻醉方式下体外循环期间体液变化的性质研究。第一组，通过以5 - 6微克/千克/小时的剂量给予芬太尼、地西泮（0.1毫克/千克/小时）和阿端（0.02毫克/千克/小时）维持麻醉。在第二观察组中，在灌注开始时给患者使用三甲曲沙（阿多那）（0.2毫克/千克），而在第三组中，在灌注期间将芬太尼剂量提高到10 - 12微克/千克/小时。得出的结论是，在体外循环期间，希望增加芬太尼剂量以在心脏手术期间获得更充分的麻醉。体外循环期间体内发生的体液变化程度作为麻醉充分性的标准。
