[透皮促进剂对吡罗昔康体外经皮渗透的影响]
[Effect of enhancers on cutaneous permeation of piroxicam in vitro].
作者信息
Xu G Q, Xi N Z, Chen G S, Jiang X G, Xu H N
机构信息
Division of Biopharmaceutics, Shanghai Medical University, China.
出版信息
Zhongguo Yao Li Xue Bao. 1991 May;12(3):235-8.
Enhancing effects on the permeation of piroxicam (Pir) through excised hairless mouse (inbred HRS mice) skin were investigated by measuring flux. Azone 1% was found to be the most effective enhancer studied, increasing the flux about 21 times. The effect of Azone was enhanced by the presence of propylene glycol. Oleic acid, ethylacetate, and ethanol promoted the diffusion of Pir. Other enhancers, such as DMSO, PEG 400, acetone, urea and salicylic acid, showed little or no effect. Pir-beta-cyclodextrin inclusion compound increased the flux about 3 times. The results revealed that lipophilic enhancers were more effective than lipophobic ones.
通过测量通量，研究了对吡罗昔康（Pir）透过切除的无毛小鼠（近交HRS小鼠）皮肤的促进作用。发现1%的氮酮是所研究的最有效的促进剂，通量增加了约21倍。丙二醇的存在增强了氮酮的作用。油酸、乙酸乙酯和乙醇促进了Pir的扩散。其他促进剂，如二甲基亚砜、聚乙二醇400、丙酮、尿素和水杨酸，作用很小或没有作用。Pir-β-环糊精包合物使通量增加了约3倍。结果表明，亲脂性促进剂比疏脂性促进剂更有效。
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