Science. 1972 Mar 24;175(4028):1366-8. doi: 10.1126/science.175.4028.1366.
Gonad-stimulating substance, a hormonal peptide released from the nervous system of starfishes, acts on the ovary to produce 1-methyladenine, an inducer of oocyte maturation. Addition of methionine to the incubation mixture of ovarian fragments and gonad-stimulating substance enhanced the production of 1-methyladenine, whereas ethionine inhibited it. Incubation of ovarian tissue with methionine alone failed to produce 1-methyladenine. Use of a radioactive label showed that methionine is a methyl donor in the biosynthesis of 1-methyladenine, suggesting that gonad-stimulating substance is involved in the methylation process.
性腺刺激物质是一种从海星神经系统释放的激素肽，作用于卵巢产生 1-甲基腺嘌呤，诱导卵母细胞成熟。在卵巢片段和性腺刺激物质的孵育混合物中添加蛋氨酸可增强 1-甲基腺嘌呤的产生，而乙硫氨酸则抑制其产生。单独用蛋氨酸孵育卵巢组织未能产生 1-甲基腺嘌呤。使用放射性标记表明蛋氨酸是 1-甲基腺嘌呤生物合成中的甲基供体，这表明性腺刺激物质参与了甲基化过程。
