Black R, Kronheim S, Sleath P, Greenstreet T, Virca G D, March C, Kupper T
Department of Protein Chemistry, Immunex Corp., Seattle, WA 98101.
Agents Actions Suppl. 1991;35:85-9.
Interleukin-1 beta (IL-1 beta) is released from an inactive precursor by a proteolytic cleavage. A monocytic protease has been identified that appears to be involved in the physiological activation of this cytokine. Two situations have been found in which precursor IL-1 beta exists without the monocytic processing enzyme, and in these cases other proteases, such as neutrophil elastase, cathepsin G and cathepsin L, may be involved in generating the active cytokine.
白细胞介素-1β（IL-1β）通过蛋白水解切割从无活性前体中释放出来。已鉴定出一种单核细胞蛋白酶，它似乎参与了这种细胞因子的生理激活过程。发现了两种情况，即无单核细胞加工酶时前体IL-1β也存在，在这些情况下，其他蛋白酶，如中性粒细胞弹性蛋白酶、组织蛋白酶G和组织蛋白酶L，可能参与产生活性细胞因子。
