Krenn V, Brand-Saberi B, Wachtler F
Histologisch-Embryologisches Institut der Universität Wien, Austria.
Am J Anat. 1991 Dec;192(4):400-6. doi: 10.1002/aja.1001920407.
Myoblasts migrate in a proximodistal direction within the avian embryonic wing bud during normal limb development. Since the presence and distribution of hyaluronic acid within the wing bud coincide with the time and with the direction of the migration of myoblasts, we microinjected hyaluronic acid into chicken wing buds that had received grafts containing quail myoblasts. It was found that injected hyaluronic acid has a strong positive effect on the migration of myoblasts: it causes a migration of myoblasts in donor-host combinations in which this is normally not the case, and it can cause migration in a proximal direction, a phenomenon not observed during normal development. From this it may be concluded that hyaluronic acid can influence myoblast migration in vivo. A similar effect could be observed after the microinjection of dextran sulfate, a synthetic compound having similar physicochemical properties. Hyaluronic acid, therefore, may play an important role in the control of the migration of myogenic cells in vivo by its physiocochemical properties.
在正常肢体发育过程中，成肌细胞在禽胚胎翼芽内沿近远轴方向迁移。由于翼芽内透明质酸的存在和分布与成肌细胞迁移的时间和方向一致，我们将透明质酸显微注射到接受了含有鹌鹑成肌细胞移植的鸡翼芽中。结果发现，注射的透明质酸对成肌细胞的迁移有很强的正向作用：它能使成肌细胞在供体 - 宿主组合中发生迁移，而在正常情况下这种组合中是不会发生迁移的，并且它能导致向近端方向的迁移，这是正常发育过程中未观察到的现象。由此可以得出结论，透明质酸可在体内影响成肌细胞的迁移。在显微注射硫酸葡聚糖（一种具有相似物理化学性质的合成化合物）后也能观察到类似的效果。因此，透明质酸可能通过其物理化学性质在体内控制生肌细胞的迁移中发挥重要作用。
