Kawamura J, Meyer J S, Terayama Y, Weathers S
Cerebral Blood Flow Laboratory, Department of Veterans Affairs Medical Center, Houston, TX 77211.
Alzheimer Dis Assoc Disord. 1991 Winter;5(4):231-9. doi: 10.1097/00002093-199100540-00002.
Local cerebral blood flow was measured in 19 patients with probable dementia of Alzheimer type (DAT) by using xenon-enhanced computerized tomography (CT) and CT densitometry to accurately differentiate white from gray matter. Patients met standard diagnostic criteria for probable DAT and results were compared with similar measures in 26 age-matched, neurologically and cognitively normal volunteers. Perfusions of frontal and occipital white matter as well as frontal, parietal, temporal, and occipital cortex were reduced in DAT compared with age-matched normals. White matter perfusion differences were not observed among DAT patients with and without risk factors for stroke. Reduced perfusion of frontal white matter correlated significantly with reduced perfusion of thalamus and putamen in patients with DAT. Results confirm the frequent association of white matter abnormalities in patients with DAT that are possibly caused by amyloid angiopathy and may contribute to cognitive impairments.
通过使用氙增强计算机断层扫描（CT）和CT密度测定法准确区分白质和灰质，对19例可能患有阿尔茨海默型痴呆（DAT）的患者进行了局部脑血流量测量。患者符合可能的DAT的标准诊断标准，并将结果与26名年龄匹配、神经和认知功能正常的志愿者的类似测量结果进行比较。与年龄匹配的正常人相比，DAT患者的额叶和枕叶白质以及额叶、顶叶、颞叶和枕叶皮质的灌注减少。在有和没有中风危险因素的DAT患者中未观察到白质灌注差异。DAT患者额叶白质灌注减少与丘脑和壳核灌注减少显著相关。结果证实了DAT患者中白质异常的频繁关联，这可能是由淀粉样血管病引起的，并可能导致认知障碍。
