Involvement of the gastric antrum in Ménétrier's disease.

Thirteen cases of Ménétrier's disease from the files of the Armed Forces Institute of Pathology that could be documented pathologically and correlated with appropriate roentgenograms were analyzed for the distribution of folds. Enlarged folds occurred in a localized area or in several areas simultaniously. The greater curvature of the body was most often involved (77 percent), but the antrum was affected in almost one-half (46 percent) of the cases; thus, the concept of relative antral sparing is not valid, and the diagnosis should be considered when there is gastric rugal enlargement in any distribution. The condition seems to be classified best as a hyperplastic gastropathy rather than a hypertrophic gastritis.