Kibbey Tohren C G, Paruchuri Rajiv, Sabatini David A, Chen Lixia
School of Civil Engineering and Environmental Science, The University of Oklahoma, Norman, Oklahoma 73019-1024, USA.
Environ Sci Technol. 2007 Aug 1;41(15):5349-56. doi: 10.1021/es070152v.
Beta-adrenergic blocking agents (beta blockers) are widely used pharmaceuticals which have been detected in the environment. Predicting the transport and ultimate fate of beta blockers in the environment requires understanding their adsorption to soils and sediments, something for which little information is currently available. The objective of this work was to examine the adsorption of three beta blockers, propranolol, metoprolol and nadolol, to a natural alluvial material, as well as to six minerals present as components of the alluvial material. Batch adsorption experiments indicate that, for most of the minerals studied, compound hydrophobicity is an important predictor of adsorption, with propranolol,the most hydrophobic compound studied, adsorbing to the greatest extent. Results further suggest that, for the minerals studied, electrostatic effects are not a good predictor of adsorption; adsorption extent was not well-predicted by either surface zeta potential or by the difference between experiment pH and point of zero charge, despite the cationic nature af the three beta blockers at experiment pH values. Experiments were conducted to examine the effect of an anionic surfactant, sodium dodecyl benzene sulfonate (SDBS), on adsorption. Results indicate that SDBS significantly increases the adsorption of propranolol to two different sorbents. This result is potentially important because surfactants such as SDBS are likely to be present in wastewater effluents with beta blockers and could influence their mobility in the environment.
β-肾上腺素能阻滞剂（β受体阻滞剂）是一类广泛使用的药物，已在环境中被检测到。预测β受体阻滞剂在环境中的迁移和最终归宿需要了解它们在土壤和沉积物上的吸附情况，而目前关于这方面的信息很少。这项工作的目的是研究三种β受体阻滞剂，即普萘洛尔、美托洛尔和纳多洛尔，在天然冲积物以及作为冲积物成分的六种矿物上的吸附情况。批量吸附实验表明，对于大多数所研究的矿物来说，化合物的疏水性是吸附的一个重要预测指标，在所研究的疏水性最强的化合物普萘洛尔吸附程度最大。结果还表明，对于所研究的矿物，静电效应不是吸附的良好预测指标；尽管在实验pH值下这三种β受体阻滞剂呈阳离子性质，但无论是表面zeta电位还是实验pH值与零电荷点之间的差异，都不能很好地预测吸附程度。进行实验以研究阴离子表面活性剂十二烷基苯磺酸钠（SDBS）对吸附的影响。结果表明，SDBS显著增加了普萘洛尔在两种不同吸附剂上的吸附。这一结果可能很重要，因为像SDBS这样的表面活性剂很可能存在于含有β受体阻滞剂的废水排放物中，并可能影响它们在环境中的迁移。
