Muthu Maharajan, Kumaar G Sampath
Rajan Hospital, Madurai 625010.
J Indian Med Assoc. 2007 Feb;105(2):82, 84, 87.
To find out whether malaria occurred at an increased frequency in HIV-infected individuals and to evaluate the clinical course and risk factors for malarial infection in HIV, a prospective study was carried out in a tertiary care centre from June, 1999 to December, 2000 among HIV-infected individuals with HIV-uninfected Individuals taken as control. In this study, out of 250 individuals, 152 were HIV-infected and the remaining were HIV-negative. The odd's ratio (OR) for the occurrence of malaria in the HIV-infected population compared with the HIV-uninfected population was 2.5 (95% confidence interval: 1.01, 6.4; p < 0.02). The prevalence of malaria in HIV infection was 20.4%. The same was 8.3% in asymptomatic stage, and 22.6% and 21.3% in the early and late symptomatic stages of HIV disease respectively. Among those who came for follow-up 44.4% of the HIV-infected individuals had recurrence of malarial infection. Contrary to what was thought before, malaria occurred at an increased frequency in HIV cases. The occurrence of malaria increased in the symptomatic stages of HIV disease compared to the asymptomatic stage. Recurrence was high in the HIV-infected population.
为了确定疟疾在艾滋病毒感染者中是否以更高的频率发生，并评估艾滋病毒感染中疟疾感染的临床病程和危险因素，于1999年6月至2000年12月在一家三级护理中心对艾滋病毒感染者进行了一项前瞻性研究，以未感染艾滋病毒的个体作为对照。在这项研究中，250名个体中，152名感染了艾滋病毒，其余为艾滋病毒阴性。与未感染艾滋病毒的人群相比，感染艾滋病毒人群中疟疾发生的优势比（OR）为2.5（95%置信区间：1.01, 6.4；p < 0.02）。艾滋病毒感染中疟疾的患病率为20.4%。在无症状阶段为8.3%，在艾滋病毒疾病的早期和晚期症状阶段分别为22.6%和21.3%。在前来随访的人群中，44.4%的艾滋病毒感染个体有疟疾感染复发。与之前的想法相反，艾滋病毒感染者中疟疾的发生频率增加。与无症状阶段相比，艾滋病毒疾病症状阶段疟疾的发生增加。艾滋病毒感染人群中复发率很高。
