Gurjar Mukund K
Department of Organic Chemistry Technology, National Chemical Laboratory, Pune 411008.
J Indian Med Assoc. 2007 Apr;105(4):177-8.
Racemates are fixed-dose combinations of stereoisomers. Each isomer may have different pharmacokinetic or pharmacodynamic properties. Recent research has allowed appreciation of the need to purify racemates and develop useful unichiral molecules. Some examples are: S-amlodipine besylate, S-atenolol, S-metoprolol succinate, S-pantoprazole sodium and R-ondansetron hydrochloride.
外消旋体是立体异构体的固定剂量组合。每种异构体可能具有不同的药代动力学或药效学特性。最近的研究使人们认识到需要纯化外消旋体并开发有用的单一手性分子。一些例子有：苯磺酸左旋氨氯地平、阿替洛尔、琥珀酸美托洛尔、泮托拉唑钠和盐酸右昂丹司琼。
