de Heer K, Silbermann M H, Koene H R, Biemond B J, Muller H P, van Oers M H J
Tergooiziekenhuizen, locatie Blaricum, afd. Interne Geneeskunde, Blaricum.
Ned Tijdschr Geneeskd. 2007 Aug 11;151(32):1770-6.
Erythrocytosis is a phenomenon with life-threatening complications and a broad differential diagnosis. Erythrocytosis is usually secondary to a cardiopulmonary condition leading to a low arterial oxygen tension. A probable diagnosis can often be made on the basis of the history, physical examination, a measurement of the peripheral oxygen saturation, and simple laboratory tests. The differential diagnosis can be narrowed down by a determination of the erythropoietin concentration and the JAK2 mutation. If the erythrocytosis is found to be non-physiological, then reduction of the haematocrit via bloodletting and, depending on the diagnosis, treatment with acetylsalicylic acid are indicated.
红细胞增多症是一种伴有危及生命并发症且鉴别诊断范围广泛的现象。红细胞增多症通常继发于心肺疾病，导致动脉血氧分压降低。通常可以根据病史、体格检查、外周血氧饱和度测量以及简单的实验室检查做出可能的诊断。通过测定促红细胞生成素浓度和JAK2突变可缩小鉴别诊断范围。如果发现红细胞增多症是非生理性的，则需要通过放血降低血细胞比容，并根据诊断使用阿司匹林进行治疗。
