Li Cheng, Hossieny Parastu, Wu Ben J, Qawasmeh Abdelqader, Beck Konstanze, Stocker Roland
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Australia.
Antioxid Redox Signal. 2007 Dec;9(12):2227-39. doi: 10.1089/ars.2007.1783.
Heme oxygenase-1 (HO-1) is a cytoprotective protein whose expression is consistently associated with therapeutic benefits in a number of pathologic conditions such as atherosclerotic vascular disease and inflammation. Although the expression of HO-1 in most tissues is low, a large number of clinical and experimental pharmacologic compounds have been demonstrated to induce HO-1. This induction is suggested to be at least partially responsible for the perceived therapeutic efficacy of these compounds. The increase in HO-1 expression in response to these compounds is the result of a complex regulatory network involving many signaling pathways and transcription factors. Understanding both the pathways by which HO-1 is induced and the mechanism through which the enzyme exerts its beneficial effects may facilitate the development of novel drugs.
血红素加氧酶-1（HO-1）是一种具有细胞保护作用的蛋白质，其表达与多种病理状况（如动脉粥样硬化性血管疾病和炎症）的治疗益处始终相关。尽管HO-1在大多数组织中的表达较低，但大量临床和实验性药理化合物已被证明可诱导HO-1表达。这种诱导作用被认为至少部分地解释了这些化合物所观察到的治疗效果。响应这些化合物而导致的HO-1表达增加是一个复杂调控网络的结果，该网络涉及许多信号通路和转录因子。了解HO-1被诱导的途径以及该酶发挥其有益作用的机制，可能有助于新型药物的开发。
