靶向端粒与端粒酶。
Targeting telomeres and telomerase.
作者信息
De Cian Anne, Lacroix Laurent, Douarre Céline, Temime-Smaali Nassima, Trentesaux Chantal, Riou Jean-François, Mergny Jean-Louis
机构信息
INSERM, U565, Acides nucléiques: dynamique, ciblage et fonctions biologiques, 43 rue Cuvier, CP26, Paris Cedex 05, F-75231, France.
出版信息
Biochimie. 2008 Jan;90(1):131-55. doi: 10.1016/j.biochi.2007.07.011. Epub 2007 Jul 24.
Telomeres and telomerase represent, at least in theory, an extremely attractive target for cancer therapy. The objective of this review is to present the latest view on the mechanism(s) of action of telomerase inhibitors, with an emphasis on a specific class of telomere ligands called G-quadruplex ligands, and to discuss their potential use in oncology.
端粒和端粒酶至少在理论上是极具吸引力的癌症治疗靶点。这篇综述的目的是阐述端粒酶抑制剂作用机制的最新观点，重点关注一类名为G-四链体配体的特定端粒配体，并探讨它们在肿瘤学中的潜在应用。
Zotero 插件