Matsunaga Daigo, Akizuki Shaw, Takizawa Tsutomu, Yamazaki Ikuya, Kuraishi Joji
Department of Orthopaedic Surgery and Rehabilitation, Nagano Matsushiro General Hospital, Nagano City, Japan.
Knee. 2007 Dec;14(6):465-71. doi: 10.1016/j.knee.2007.06.008. Epub 2007 Sep 5.
This study compared the healing of articular cartilage and the clinical outcome after osteotomy with or without marrow stimulation microfracture or abrasion arthroplasty for osteoarthritis of the knee. Patients with osteoarthritis of the medial compartment of the knee were divided into a group undergoing high tibial osteotomy alone (HTO group: 37 knees), a group undergoing osteotomy plus microfracture (MF group: 26 knees), and a group undergoing osteotomy plus abrasion arthroplasty (AA group: 51 knees). The extent of cartilage repair was compared at 1 year after surgery by arthroscopy with reference to Outerbridge's classification, while the clinical outcome was compared at 1, 3, and 5 years postoperatively. Second-look arthroscopy revealed better repair of the femoral condylar cartilage in the AA group than the HTO group (p<0.0005) or MF group (p<0.01), with no difference between the HTO and MF groups. Repair of the tibial condylar cartilage was also better in the AA group than the HTO group (p<0.005), but there was no difference between the AA and MF groups or the MF and HTO groups. There were no differences of the clinical outcome between the three groups. In conclusion, repair of articular cartilage at 1 year postoperatively was accelerated by abrasion arthroplasty, but not by microfracture. However, there was no difference of the clinical outcome within 5 years after surgery, so the clinical utility of marrow stimulation techniques was not apparent in this study.
本研究比较了膝关节骨关节炎患者在进行或不进行骨髓刺激微骨折或磨削关节成形术的截骨术后关节软骨的愈合情况及临床疗效。膝关节内侧间室骨关节炎患者被分为单纯接受高位胫骨截骨术的组(HTO组:37个膝关节)、接受截骨术加微骨折的组(MF组:26个膝关节)和接受截骨术加磨削关节成形术的组(AA组:51个膝关节)。术后1年通过关节镜检查参照Outerbridge分类法比较软骨修复程度,同时在术后1年、3年和5年比较临床疗效。二次关节镜检查显示,AA组股骨髁软骨的修复情况优于HTO组(p<0.0005)或MF组(p<0.01),HTO组和MF组之间无差异。AA组胫骨髁软骨的修复情况也优于HTO组(p<0.005),但AA组和MF组之间以及MF组和HTO组之间无差异。三组之间的临床疗效无差异。总之,术后1年时,磨削关节成形术可加速关节软骨修复,而微骨折则不能。然而,术后5年内临床疗效无差异,因此在本研究中骨髓刺激技术的临床实用性并不明显。