50例接受丘脑底核深部脑刺激治疗的帕金森病患者的长期预后
Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation.
作者信息
Wider C, Pollo C, Bloch J, Burkhard P R, Vingerhoets F J G
机构信息
Department of Neurology, CHUV, Rue du Bugnon, 1011 Lausanne, Switzerland.
出版信息
Parkinsonism Relat Disord. 2008;14(2):114-9. doi: 10.1016/j.parkreldis.2007.06.012. Epub 2007 Sep 5.
OBJECTIVE
To describe the long-term outcome in 50 consecutive advanced Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS).
METHOD
Assessments were carried out at baseline, 6 months, 2 years, and 5 years postoperatively.
RESULTS
Compared to baseline scores without medication, we found a highly significant improvement of UPDRS III with stimulation, maintained at 5 years (p<0.001). This improvement, however, tended to diminish over time. Dyskinesia and off periods were also improved (p<0.0001 for both). Seventeen patients died during follow-up, who tended to be older at surgery (p<0.01).
CONCLUSIONS
STN-DBS is an effective treatment for advanced PD patients, and the beneficial effect is maintained at 5 years. However, worsening occurs over time due to disease progression.
目的
描述连续50例接受丘脑底核脑深部电刺激术（STN-DBS）治疗的晚期帕金森病（PD）患者的长期预后。
方法
在术后基线、6个月、2年和5年进行评估。
结果
与未用药时的基线评分相比，我们发现刺激时统一帕金森病评定量表第三部分（UPDRS III）有显著改善，且在5年时仍保持（p<0.001）。然而，这种改善随时间推移有减弱趋势。异动症和“关”期也有所改善（两者p均<0.0001）。17例患者在随访期间死亡，他们手术时年龄往往较大（p<0.01）。
结论
STN-DBS是晚期PD患者的有效治疗方法，有益效果可持续5年。然而，由于疾病进展，随时间会出现病情恶化。
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