Chisvert León J, Valderrábano Quintana F
Laboratorio de Radioinmunoanálisis, Clínica Nervión, Madrid.
An Med Interna. 1991 Dec;8(12):587-94.
The purpose of this study is to assess hormonal disorders of the hypophysis-gonad axis in 92 patients with chronic renal failure undergoing hemodialysis and in 14 patients after renal transplantation; concentrations of testosterone, free testosterone, estradiol, progesterone, gonadotropins and prolactin are analyzed. We have tried to establish typical alteration patterns, and to this effect, we have analyzed the results according to the etiology of chronic renal failure and to the impact of several dialysis factors on the hormones assessed. A typical patterns of hormonal disorder in the hypophysis-gonad axis has not been observed, nor a disorder that may be typical of a given etiology. Hyperprolactinemia affects men and women in equal proportion. No impact of dialysis factors on hormonal disorders has been observed. After renal transplantation, hormonal disorders disappear and normality of hypophysis-gonad axis is restored.
本研究旨在评估92例接受血液透析的慢性肾衰竭患者及14例肾移植后患者垂体-性腺轴的激素紊乱情况；分析睾酮、游离睾酮、雌二醇、孕酮、促性腺激素和催乳素的浓度。我们试图建立典型的改变模式，为此，我们根据慢性肾衰竭的病因以及几种透析因素对所评估激素的影响来分析结果。未观察到垂体-性腺轴激素紊乱的典型模式，也未观察到特定病因可能具有的典型紊乱情况。高催乳素血症对男性和女性的影响比例相同。未观察到透析因素对激素紊乱有影响。肾移植后，激素紊乱消失，垂体-性腺轴恢复正常。
