Blanes A, Villar A, Amigó V, Monzó E, González Sal M
Servicio de Medicina Interna, Hospital Arnau de Vilanova, Valencia.
An Med Interna. 1991 Dec;8(12):605-8.
A clinical case of a 55-year-old man with syndrome of primary Sjögren, seronegative, normoglobulinemic and normocomplementary with 7 years of evolution, which developed acute lymphoblastic leukemia, having suffered recurrent lympho-adenopathy and paresthetic meralgia as previous clinical signs, is presented. Clinical, serological and immunologic characteristics of this syndrome are reviewed, highlighting its rare appearance among men. While appearance of malignant lymphoproliferation disorders is well known, evolution to acute or chronic myeloid leukemia is very rare and so far, an acute lymphoblastic leukemia as the one presented in this study has never been described.
报告了一例55岁男性原发性干燥综合征患者的临床病例，该患者血清学阴性、球蛋白正常、补体正常，病程7年，并发急性淋巴细胞白血病，此前有复发性淋巴结病和感觉异常性股痛等临床症状。本文回顾了该综合征的临床、血清学和免疫学特征，强调其在男性中罕见。虽然恶性淋巴增殖性疾病的出现已为人熟知，但演变为急性或慢性髓系白血病非常罕见，迄今为止，尚未有像本研究中所呈现的急性淋巴细胞白血病的相关描述。
