Bairey O, Shaklai M, Inbal A
Division of Hematology, Beilinson Medical Center, Petah Tiqva, Israel.
Blood Coagul Fibrinolysis. 1991 Oct;2(5):669-71. doi: 10.1097/00001721-199110000-00014.
While haemarthrosis is a common finding in severe factor VIII or IX deficiency, it is unusual in mild coagulation factor deficiencies. We describe three patients with mild factor IX, X or XI deficiency who presented with spontaneous haemarthrosis. All underwent joint puncture with subsequent worsening of the haemarthrosis in the affected joint. This report indicates that: (i) even mild coagulation factor deficiency may be associated with haemarthrosis; (ii) patients with suspected haemarthrosis should undergo routine screening coagulation tests before joint puncture; and (iii) any abnormalities in the screening tests indicate a need for further evaluation of the coagulation status. In such cases puncture of the joint should be deferred and specific therapy started immediately.
虽然关节积血在严重的凝血因子 VIII 或 IX 缺乏症中很常见，但在轻度凝血因子缺乏症中并不常见。我们描述了三名患有轻度凝血因子 IX、X 或 XI 缺乏症且出现自发性关节积血的患者。所有患者均接受了关节穿刺，随后受累关节的关节积血情况恶化。本报告表明：（i）即使是轻度凝血因子缺乏也可能与关节积血有关；（ii）疑似关节积血的患者在关节穿刺前应进行常规凝血筛查试验；（iii）筛查试验中的任何异常都表明需要进一步评估凝血状态。在这种情况下，应推迟关节穿刺并立即开始特异性治疗。
