Norata Giuseppe Danilo, Raselli Sara, Grigore Liliana, Garlaschelli Katia, Dozio Elena, Magni Paolo, Catapano Alberico L
Stroke. 2007 Oct;38(10):2844-6. doi: 10.1161/STROKEAHA.107.485540. Epub 2007 Sep 6.
The evaluation of the leptin:adiponectin ratio (L:A) has been suggested as an atherosclerotic index in patients with type 2 diabetes and a useful parameter to assess insulin resistance in patients with and without diabetes.
We investigated, therefore, the relationship between L:A ratio and intima media thickness (IMT), an independent predictor of cardiovascular disease, in 110 healthy males.
L:A ratio was significantly correlated to body mass index, waist, hip, waist-to-hip ratio, systolic blood pressure, IMT, high-density lipoprotein, apolipoprotein A-I, glucose, and the homeostasis model of insulin resistance-revised. No significant correlation was observed with age, diastolic blood pressure, low-density lipoprotein, triglycerides, apolipoprotein B, ApoB/ApoA-I ratio, insulin, alanine transaminase, gamma-glutamyl-transferase, and resistin. In addition, when the relationship between IMT and adiponectin or leptin alone was analyzed, only leptin plasma levels significantly associated with IMT (r=0.301, P<0.01). In a multiple regression analysis including in the statistical model the risk factors known to affect IMT (age, systolic blood pressure, diastolic blood pressure, high-density lipoprotein cholesterol, triglycerides, total cholesterol, body mass index, glucose, and L:A ratio), we observed that only age, L:A, and glucose were independent predictors of IMT. As expected, obese subjects (body mass index >30 kg/m(2)) showed a significantly higher L:A ratio compared with nonobese subjects (1.20 versus 0.42, respectively, P<0.001); in addition, subjects with the metabolic syndrome showed a significantly higher L:A ratio level (0.79) compared with subjects without (0.52) (P<0.01).
We show here that the L:A ratio is a powerful independent predictor of IMT in healthy subjects and correlates with several anthropometric, metabolic, and clinical parameters better than each single adipokine.
瘦素与脂联素比值（L:A）已被提议作为2型糖尿病患者的动脉粥样硬化指标，也是评估糖尿病患者和非糖尿病患者胰岛素抵抗的一个有用参数。
因此，我们在110名健康男性中研究了L:A比值与内膜中层厚度（IMT）（心血管疾病的一个独立预测指标）之间的关系。
L:A比值与体重指数、腰围、臀围、腰臀比、收缩压、IMT、高密度脂蛋白、载脂蛋白A-I、血糖以及修订后的胰岛素抵抗稳态模型显著相关。未观察到与年龄、舒张压、低密度脂蛋白、甘油三酯、载脂蛋白B、ApoB/ApoA-I比值、胰岛素、丙氨酸转氨酶、γ-谷氨酰转移酶和抵抗素之间存在显著相关性。此外，当单独分析IMT与脂联素或瘦素之间的关系时，只有瘦素血浆水平与IMT显著相关（r = 0.301，P < 0.01）。在一个多元回归分析中，将已知影响IMT的危险因素（年龄、收缩压、舒张压、高密度脂蛋白胆固醇、甘油三酯、总胆固醇、体重指数、血糖和L:A比值）纳入统计模型，我们观察到只有年龄、L:A和血糖是IMT的独立预测指标。正如预期的那样，肥胖受试者（体重指数>30 kg/m²）的L:A比值显著高于非肥胖受试者（分别为1.20和0.42，P < 0.001）；此外，代谢综合征患者的L:A比值水平（0.79）显著高于无代谢综合征患者（0.52）（P < 0.01）。
我们在此表明，L:A比值是健康受试者IMT的一个有力独立预测指标，并且与多个体测量、代谢和临床参数的相关性优于单一的脂肪因子。
