Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Cardiovasc Diabetol. 2023 Aug 31;22(1):231. doi: 10.1186/s12933-023-01968-4.
Adipokines are hormones secreted from adipose tissue and are associated with cardiometabolic diseases (CMD). Functional differences between adipokines (leptin, adiponectin, and resistin) are known, but inconsistently reported associations with CMD and lack of studies in Hispanic populations are research gaps. We investigated the relationship between subclinical atherosclerosis and multiple adipokine measures.
Cross-sectional data from the Cameron County Hispanic Cohort (N = 624; mean age = 50; Female = 70.8%) were utilized to assess associations between adipokines [continuous measures of adiponectin, leptin, resistin, leptin-to-adiponectin ratio (LAR), and adiponectin-resistin index (ARI)] and early atherosclerosis [carotid-intima media thickness (cIMT)]. We adjusted for sex, age, body mass index (BMI), smoking status, cytokines, fasting blood glucose levels, blood pressure, lipid levels, and medication usage in the fully adjusted linear regression model. We conducted sexes-combined and sex-stratified analyses to account for sex-specificity and additionally tested whether stratification of participants by their metabolic status (metabolically elevated risk for CMD as defined by having two or more of the following conditions: hypertension, dyslipidemia, insulin resistance, and inflammation vs. not) influenced the relationship between adipokines and cIMT.
In the fully adjusted analyses, adiponectin, leptin, and LAR displayed significant interaction by sex (p < 0.1). Male-specific associations were between cIMT and LAR [β(SE) = 0.060 (0.016), p = 2.52 × 10], and female-specific associations were between cIMT and adiponectin [β(SE) = 0.010 (0.005), p = 0.043] and ARI [β(SE) = - 0.011 (0.005), p = 0.036]. When stratified by metabolic health status, the male-specific positive association between LAR and cIMT was more evident among the metabolically healthy group [β(SE) = 0.127 (0.015), p = 4.70 × 10] (p for interaction by metabolic health < 0.1). However, the female-specific associations between adiponectin and cIMT and ARI and cIMT were observed only among the metabolically elevated risk group [β(SE) = 0.014 (0.005), p = 0.012 for adiponectin; β(SE) = - 0.015 (0.006), p = 0.013 for ARI; p for interaction by metabolic health < 0.1].
Associations between adipokines and cIMT were sex-specific, and metabolic health status influenced the relationships between adipokines and cIMT. These heterogeneities by sex and metabolic health affirm the complex relationships between adipokines and atherosclerosis.
脂肪因子是由脂肪组织分泌的激素，与心脏代谢疾病（CMD）有关。脂肪因子（瘦素、脂联素和抵抗素）的功能存在差异，但与 CMD 的关联不一致，且缺乏西班牙裔人群的研究，这些都是研究空白。我们研究了亚临床动脉粥样硬化与多种脂肪因子测量值之间的关系。
利用卡梅伦县西班牙裔队列（N=624；平均年龄=50；女性=70.8%）的横断面数据，评估脂肪因子[脂联素、瘦素、抵抗素、瘦素与脂联素比值（LAR）和脂联素-抵抗素指数（ARI）的连续测量值]与早期动脉粥样硬化[颈动脉内膜中层厚度（cIMT）]之间的相关性。我们在完全调整的线性回归模型中调整了性别、年龄、体重指数（BMI）、吸烟状况、细胞因子、空腹血糖水平、血压、血脂水平和药物使用情况。我们进行了性别合并和性别分层分析，以考虑性别特异性，并进一步测试了根据参与者的代谢状态（定义为具有以下两种或两种以上条件的 CMD 代谢升高风险：高血压、血脂异常、胰岛素抵抗和炎症与不具有）对脂肪因子与 cIMT 之间的关系进行分层是否会影响这种关系。
在完全调整的分析中，脂联素、瘦素和 LAR 的性别交互作用具有统计学意义（p<0.1）。男性特有的相关性是 cIMT 与 LAR 之间的相关性[β（SE）=0.060（0.016），p=2.52×10]，女性特有的相关性是 cIMT 与脂联素[β（SE）=0.010（0.005），p=0.043]和 ARI[β（SE）=−0.011（0.005），p=0.036]之间的相关性。当按代谢健康状况分层时，LAR 与 cIMT 之间的男性特有的正相关性在代谢健康组中更为明显[β（SE）=0.127（0.015），p=4.70×10]（p 交互作用<0.1）。然而，只有在代谢升高风险组中才观察到脂联素与 cIMT 和 ARI 与 cIMT 之间的女性特异性相关性[β（SE）=0.014（0.005），p=0.012 脂联素；β（SE）=−0.015（0.006），p=0.013 ARI；p 交互作用<0.1]。
脂肪因子与 cIMT 的相关性具有性别特异性，代谢健康状况影响脂肪因子与 cIMT 的关系。这些性别和代谢健康状况的异质性证实了脂肪因子与动脉粥样硬化之间的复杂关系。
Zotero 插件