利多卡因贴片应用后犬体内利多卡因的血浆浓度。
Plasma concentrations of lidocaine in dogs following lidocaine patch application.
作者信息
Ko Jeff, Weil Ann, Maxwell Lara, Kitao Takashi, Haydon Todd
机构信息
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA.
出版信息
J Am Anim Hosp Assoc. 2007 Sep-Oct;43(5):280-3. doi: 10.5326/0430280.
Transdermal absorption of lidocaine was determined by measuring plasma lidocaine concentrations following skin application of 5% lidocaine patches. Two lidocaine patches were placed on the ventral abdominal midline of seven dogs for 72 hours. Lidocaine was detectable in plasma 12 hours after patch application, and it reached steady-state concentrations between 24 and 48 hours. Plasma lidocaine levels decreased dramatically at 60 hours post-application. Low plasma lidocaine concentrations remained for 6 hours after patch removal. No clinically significant side effects were noted.
通过测量在皮肤应用5%利多卡因贴片后血浆利多卡因浓度来确定利多卡因的经皮吸收情况。将两片利多卡因贴片放置在7只狗的腹中线腹部72小时。贴片应用后12小时在血浆中可检测到利多卡因，并且在24至48小时之间达到稳态浓度。应用后60小时血浆利多卡因水平急剧下降。贴片去除后低血浆利多卡因浓度持续6小时。未观察到具有临床意义的副作用。
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