Buchanan Jessica B, Johnson Rodney W
Laboratory of Integrative Immunology and Behaviour, Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Neuroendocrinology. 2007;86(3):183-90. doi: 10.1159/000108280. Epub 2007 Sep 7.
A number of inflammatory cytokines are synthesized and released after activation of the immune system. In addition to other biological effects, these cytokines can potently inhibit food intake. Cytokine-mediated inhibition of food intake is of particular importance because excessive production of peripheral inflammatory cytokines is often associated with the cachexia-anorexia syndrome seen in some chronic diseases. The weight loss in cachexia is associated with an increase in morbidity and mortality. Understanding how cytokines regulate food intake may be crucial in enhancing quality of life and facilitating recovery in patients exhibiting cachexia. This review describes the main inflammatory cytokines that influence food intake and explores how peripheral cytokines communicate with hypothalamic nuclei to influence feeding.
免疫系统激活后会合成并释放多种炎性细胞因子。除了其他生物学效应外，这些细胞因子还能有效抑制食物摄入。细胞因子介导的食物摄入抑制尤为重要，因为外周炎性细胞因子的过度产生通常与某些慢性疾病中出现的恶病质-厌食综合征相关。恶病质中的体重减轻与发病率和死亡率的增加有关。了解细胞因子如何调节食物摄入对于提高恶病质患者的生活质量和促进康复可能至关重要。这篇综述描述了影响食物摄入的主要炎性细胞因子，并探讨了外周细胞因子如何与下丘脑核团相互作用以影响进食。
