Procaccini Enrico M, Napolitano Alessandra, Panzella Lucia, Prizio Emilia, Monfrecola Giuseppe
Azienda Sanitaria Locale, ASL NA1, Università degli Studi di Napoli Federico II, Napoli, Italy.
Dermatology. 2007;215(3):173-9. doi: 10.1159/000106572.
The currently adopted method for predicting sun sensitivity is Fitzpatrick's classification which however is based on self-reported burning tendency and tanning ability.
Determination of the individual UV susceptibility based on non-subjective parameters.
Minimal erythema dose (MED), intensity and duration of pigmentation on days 5, 9 and 16 following 1 MED and the levels of the melanin marker pyrrole-2,3,5-tricarboxylic acid (PTCA) were analysed in non-red-haired subjects (50, aged 20-46 years).
Phenotype groups or phototypes showed a good correlation with PTCA yields and the persistence of pigmentation on day 16, but not with MED values. MED values did not show a significant correlation with PTCA yields. On the other hand, high values on day 16 were exhibited only by subjects having PTCA values higher than 200 ng/mg.
Measurement persistence of pigmentation on day 16 represents a non-invasive and easy-to-perform method to evaluate photoprotection in those individuals escaping straightforward classification based on phenotype or anamnesis.
目前采用的预测日晒敏感性的方法是菲茨帕特里克分类法,然而该方法是基于自我报告的晒伤倾向和晒黑能力。
基于非主观参数确定个体对紫外线的易感性。
对非红发受试者(50名,年龄20 - 46岁)分析其最小红斑量(MED)、在1个MED照射后第5天、第9天和第16天的色素沉着强度和持续时间,以及黑色素标志物吡咯 - 2,3,5 - 三羧酸(PTCA)的水平。
表型组或光型与PTCA产量以及第16天色素沉着的持续性具有良好的相关性,但与MED值无关。MED值与PTCA产量未显示出显著相关性。另一方面,只有PTCA值高于200 ng/mg的受试者在第16天表现出高值。
测量第16天色素沉着的持续性是一种非侵入性且易于实施的方法,可用于评估那些无法根据表型或既往史进行直接分类的个体的光防护情况。