痤疮患者家庭接触者的上呼吸道感染

Upper respiratory tract infection in household contacts of acne patients.

作者信息

Bowe Whitney P, Hoffstad Ole, Margolis David J

机构信息

Department of Dermatology, University of Pennsylvania Center for Education and Research in Therapeutics, Philadelphia, PA, USA.

出版信息

Dermatology. 2007;215(3):213-8. doi: 10.1159/000106579.

DOI:10.1159/000106579

PMID:17823518

Abstract

BACKGROUND

Antibiotic use in acne patients has been associated with an increased risk of upper respiratory tract infection (URTI).

METHODS

This was a retrospective cohort study using the General Practice Research Database of the United Kingdom. All study subjects were identified as sharing a residence with a patient with a diagnosis of acne. Outcome of interest was a URTI.

RESULTS

We identified 98,094 contacts of acne patients. A contact of an acne patient who had a URTI was about 43% more likely to develop a URTI than a contact of an acne patient who did not have a URTI (OR = 1.43 CI = 1.33-1.52, p < 0.001). Exposure to an acne patient using antibiotics did not independently increase a contact's risk of URTI (OR = 0.94, CI = 0.89-1.00, p = 0.063).

CONCLUSIONS

Although acne patients on antibiotics are about 2 times more likely to develop URTIs, their household contacts do not appear to be at an increased risk of URTI.

摘要

背景

痤疮患者使用抗生素与上呼吸道感染（URTI）风险增加有关。

方法

这是一项使用英国全科医学研究数据库的回顾性队列研究。所有研究对象均被确定为与一名诊断为痤疮的患者同住。感兴趣的结局是上呼吸道感染。

结果

我们确定了98,094名痤疮患者的接触者。患有上呼吸道感染的痤疮患者的接触者发生上呼吸道感染的可能性比未患该疾病的痤疮患者的接触者高约43%（比值比=1.43，可信区间=1.33 - 1.52，p<0.001）。接触使用抗生素的痤疮患者并不会独立增加接触者发生上呼吸道感染的风险（比值比=0.94，可信区间=0.89 - 1.00，p = 0.063）。