The BioArte Ltd., Malta Life Science Park, Triq San Giljan, SGN 3000 San Gwann, Malta.
Int J Mol Sci. 2024 Oct 24;25(21):11422. doi: 10.3390/ijms252111422.
Acne vulgaris is a widespread dermatological condition that significantly affects the quality of life of adolescents and adults. Traditionally, acne pathogenesis has been linked to factors such as excess sebum production, follicular hyperkeratinization, and the presence of (). However, recent studies have highlighted the role of the skin microbiome, shifting focus from individual pathogens to microbial community dynamics. This review critically evaluates existing research on the skin microbiome and its relationship to acne, focusing on microbial diversity, strain variability, and emerging therapies targeting the microbiome. While certain studies associate with acne severity, others show this bacterium's presence in healthy skin, suggesting that strain-specific differences and overall microbial balance play crucial roles. Emerging therapeutic approaches, such as probiotics and bacteriophage therapy, aim to restore microbial equilibrium or selectively target pathogenic strains without disturbing the broader microbiome. However, the lack of standardized methodologies, limited longitudinal studies, and the narrow focus on bacterial communities are major limitations in current research. Future research should explore the broader skin microbiome, including fungi and viruses, use consistent methodologies, and focus on longitudinal studies to better understand microbial fluctuations over time. Addressing these gaps will enable the development of more effective microbiome-based treatments for acne. In conclusion, while microbiome-targeted therapies hold promise, further investigation is needed to validate their efficacy and safety, paving the way for innovative, personalized acne management strategies.
寻常痤疮是一种广泛存在的皮肤疾病，它会显著影响青少年和成年人的生活质量。传统上，痤疮的发病机制与皮脂过度分泌、毛囊过度角化以及（）的存在等因素有关。然而，最近的研究强调了皮肤微生物组的作用，研究重点从单一病原体转移到了微生物群落动态。本综述批判性地评估了皮肤微生物组及其与痤疮的关系的现有研究，重点关注微生物多样性、（）变异性和针对微生物组的新兴治疗方法。虽然某些研究将（）与痤疮严重程度相关联，但其他研究表明这种细菌也存在于健康的皮肤中，这表明菌株特异性差异和整体微生物平衡起着至关重要的作用。新兴的治疗方法，如益生菌和噬菌体疗法，旨在恢复微生物平衡或有选择地靶向致病菌株，而不干扰更广泛的微生物组。然而，目前研究存在缺乏标准化方法学、有限的纵向研究以及对细菌群落的狭隘关注等局限性。未来的研究应探索更广泛的皮肤微生物组，包括真菌和病毒，使用一致的方法学，并侧重于纵向研究，以更好地了解微生物随时间的波动。解决这些差距将为开发更有效的基于微生物组的痤疮治疗方法铺平道路。总之，尽管针对微生物组的治疗方法具有潜力，但仍需要进一步的研究来验证其疗效和安全性，为创新的、个性化的痤疮管理策略铺平道路。
