Seow Chun Y, Paré Peter D
Department of Pathology and Laboratory Medicine and the James Hogg iCAPTURE Centre, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
Can J Physiol Pharmacol. 2007 Jul;85(7):659-65. doi: 10.1139/Y07-052.
The sliding filament theory of contraction that was developed for striated muscle is generally believed to be also applicable to smooth muscle. However, the well-organized myofilament lattice (i.e., the sarcomeric structure) found in striated muscle has never been clearly delineated in smooth muscle. There is evidence that the myofilament lattice in some smooth muscles, such as airway smooth muscle, is malleable; it can be reshaped to fit a large range of cell dimensions while the maximal overlap between the contractile filaments is maintained. In this review, some early models of the structurally static contractile apparatus of smooth muscle are described. The focus of the review, however, is on the recent findings supporting a model of structurally dynamic contractile apparatus and cytoskeleton for airway smooth muscle. A list of unanswered questions regarding smooth muscle ultrastructure is also proposed in this review, in the hope that it will provide some guidance for future research.
为横纹肌提出的收缩丝滑动理论通常被认为也适用于平滑肌。然而，横纹肌中发现的组织良好的肌丝晶格（即肌节结构）在平滑肌中从未被清晰地描绘出来。有证据表明，一些平滑肌，如气道平滑肌中的肌丝晶格具有可塑性；它可以重塑以适应大范围的细胞尺寸，同时保持收缩丝之间的最大重叠。在这篇综述中，描述了一些早期的平滑肌结构静态收缩装置模型。然而，综述的重点是支持气道平滑肌结构动态收缩装置和细胞骨架模型的最新发现。本综述还提出了一系列关于平滑肌超微结构的未解决问题，希望能为未来的研究提供一些指导。
