Tran Thai, Halayko Andrew J
Department of Physiology, University of Manitoba, Winnipeg, MB, Canada.
Can J Physiol Pharmacol. 2007 Jul;85(7):666-71. doi: 10.1139/Y07-050.
The airway smooth muscle from asthmatic airways produces increased amounts and an altered composition of extracellular matrix proteins. The extracellular matrix can in turn influence the phenotype and function of airway smooth muscle cells, affecting the biochemical, geometric, and mechanical properties of the airway wall. This review provides a brief overview of the current understanding of the biology associated with airway smooth muscle interactions with the extracellular matrix. We present future directions needed for the study of cellular and molecular mechanisms that determine the outcomes of extracellular matrix - airway smooth muscle interactions, and discuss their possible importance as determinants of airway function in asthma.
哮喘气道的气道平滑肌会产生数量增加且组成改变的细胞外基质蛋白。细胞外基质反过来又会影响气道平滑肌细胞的表型和功能，进而影响气道壁的生化、几何和力学特性。本综述简要概述了目前对气道平滑肌与细胞外基质相互作用相关生物学的理解。我们提出了研究决定细胞外基质与气道平滑肌相互作用结果的细胞和分子机制所需的未来方向，并讨论了它们作为哮喘气道功能决定因素的可能重要性。
