Duran Fabio L S, Zampieri Fernando G, Bottino Cassio C M, Buchpiguel Carlos A, Busatto Geraldo F
Institute of Psychiatry, São Paulo University, Medical College Hospital, São Paulo, Brazil.
Clinics (Sao Paulo). 2007 Aug;62(4):377-84. doi: 10.1590/s1807-59322007000400002.
To evaluate the feasibility of using the Statistical Parametric Mapping (SPM) program for an automated, voxel-by-voxel assessment of regional cerebral blood flow (rCBF) deficits in Alzheimer's disease (AD) subjects relative to age-matched controls studied with a conventional, single-detector SPECT system.
We used a databank of 99mTc-HMPAO images of 19 patients with a diagnosis of probable AD and 15 elderly healthy volunteers; data were acquired using an Orbiter-Siemens single-detector SPECT system. Using SPM, images were transformed spatially, smoothed (12mm), and the data were compared on a voxel-by-voxel basis with t-tests.
There were significant rCBF reductions in AD patients relative to controls involving regions predicted a priori to be affected in AD, namely the left temporal and parietal neocortices, and the right posterior cingulate gyrus (p<0.05, corrected for multiple comparisons).
The location of rCBF reductions in AD subjects in our study is consistent with the deficits detected in previous functional imaging studies of AD using higher-resolution devices. This suggests the potential usefulness of using SPM for the analysis of data acquired with single-detector SPECT systems, despite the limited sensitivity and spatial resolution of such equipment.
评估使用统计参数映射（SPM）程序对阿尔茨海默病（AD）患者相对于年龄匹配的对照者进行全脑体素逐点区域脑血流（rCBF）缺损自动评估的可行性，这些对照者使用传统的单探测器SPECT系统进行研究。
我们使用了一个数据库，其中包含19例诊断为可能AD的患者和15名老年健康志愿者的99mTc-HMPAO图像；数据使用Orbiter-西门子单探测器SPECT系统采集。使用SPM，对图像进行空间变换、平滑处理（12mm），并通过t检验在全脑体素逐点基础上比较数据。
与对照者相比，AD患者的rCBF有显著降低，涉及先前预测在AD中会受影响的区域，即左侧颞叶和顶叶新皮质以及右侧后扣带回（p<0.05，经多重比较校正）。
在我们的研究中AD患者rCBF降低的位置与先前使用高分辨率设备对AD进行的功能成像研究中检测到的缺损一致。这表明尽管此类设备的灵敏度和空间分辨率有限，但使用SPM分析单探测器SPECT系统采集的数据仍具有潜在的实用性。
