用于甲亚胺叶立德对映选择性1,3-偶极环加成反应的可回收（R）-和（S）-联萘酚-Ag（I）配合物。

Recoverable (R)- and (S)-binap-Ag(I) complexes for the enantioselective 1,3-dipolar cycloaddition reaction of azomethine ylides.

作者信息

Nájera Carmen, Retamosa M de Gracia, Sansano José M

机构信息

Departamento de Química OrgAnica and Instituto de Síntesis OrgAnica (ISO), Facultad de Ciencias, Universidad de Alicante, 03080-Alicante, Spain.

出版信息

Org Lett. 2007 Sep 27;9(20):4025-8. doi: 10.1021/ol701577k. Epub 2007 Sep 8.

DOI:10.1021/ol701577k

PMID:17824706

Abstract

The first enantioselective 1,3-dipolar cycloaddition reaction of amino acid derived azomethine ylides and maleimides catalyzed by very stable and recyclable chiral (R)- or (S)-binap-AgClO(4) complexes is described. The reactions are performed at room temperature, in good yields, with high endo diastereoselectivity and enantioselectivity, the complex being recovered by simple filtration.

摘要

描述了由非常稳定且可回收的手性（R）-或（S）-联萘酚-AgClO₄络合物催化的氨基酸衍生的甲亚胺叶立德与马来酰亚胺的首例对映选择性1,3-偶极环加成反应。反应在室温下进行，产率良好，具有高的内型非对映选择性和对映选择性，通过简单过滤即可回收该络合物。