Wang Chun-Jiang, Liang Gang, Xue Zhi-Yong, Gao Feng
College of Chemistry and Molecular Sciences, Wuhan University, PR China 430072.
J Am Chem Soc. 2008 Dec 24;130(51):17250-1. doi: 10.1021/ja807669q.
A new and highly efficient Cu(I)/TF-BiphamPhos catalytic system exhibited excellent reactivity, enantio-/diastereoselectivity, and structural scope in asymmetric 1,3-dipolar cycloaddition of azomethine ylides with 0.1-3 mol % of catalyst loading. The present methodology is the best result for asymmetric cycloaddition of azomethine ylides, especially derived from amino esters other than glycinate in terms of reactivity and enantioselectivity.
一种新型高效的Cu(I)/TF-BiphamPhos催化体系，在甲亚胺叶立德的不对称1,3-偶极环加成反应中，以0.1 - 3 mol%的催化剂负载量表现出优异的反应活性、对映/非对映选择性和结构适应性。就反应活性和对映选择性而言，本方法是甲亚胺叶立德不对称环加成反应的最佳结果，尤其是对于源自甘氨酸酯以外的氨基酯的甲亚胺叶立德。
