Hening Wayne, Allen Richard P, Tenzer Penny, Winkelman John W
Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, USA.
Geriatrics. 2007 Sep;62(9):26-9.
Restless legs syndrome (RLS) is a sensorimotor disorder characterized by a distressing urge to move the legs and sometimes other parts of the body. Diagnosis is based on clinical features that may be easily remembered with the mnemonic URGE: Urge to move, Rest induced, Gets better with activity, and Evening and night accentuation. RLS is common, its prevalence increases with age, and women are more frequently affected. The course is chronic with often severe sleep disruption, including periodic leg movements. Differential diagnosis includes disorders of restlessness and leg discomfort. Primary RLS is familial and likely to be genetic. Important causes of secondary RLS are end-stage renal disease, pregnancy, and iron deficiency. Every patient should be checked for iron status with a serum ferritin measurement.
不宁腿综合征（RLS）是一种感觉运动障碍，其特征是腿部以及有时身体其他部位有一种令人痛苦的活动冲动。诊断基于临床特征，这些特征可用助记符URGE轻松记住：活动冲动、休息诱发、活动后改善以及傍晚和夜间加重。RLS很常见，其患病率随年龄增长而增加，女性更易受影响。病程呈慢性，常伴有严重的睡眠中断，包括周期性腿部运动。鉴别诊断包括不安和腿部不适的疾病。原发性RLS具有家族性，可能是遗传性的。继发性RLS的重要原因是终末期肾病、妊娠和缺铁。每位患者都应通过检测血清铁蛋白来检查铁状态。
